ENHANCED T-HELPER 2 LYMPHOCYTE-RESPONSES - IMMUNE MECHANISM OF HELICOBACTER-PYLORI INFECTION

Citation
Xg. Fan et al., ENHANCED T-HELPER 2 LYMPHOCYTE-RESPONSES - IMMUNE MECHANISM OF HELICOBACTER-PYLORI INFECTION, Irish journal of medical science, 165(1), 1996, pp. 37-39
Citations number
30
Categorie Soggetti
Medicine, General & Internal
ISSN journal
00211265
Volume
165
Issue
1
Year of publication
1996
Pages
37 - 39
Database
ISI
SICI code
0021-1265(1996)165:1<37:ET2L-I>2.0.ZU;2-7
Abstract
Several lines of evidence implicate Helicobacter pylori (H. pylori) in fection in gastroduodenal inflammation. However, the exact pathogenesi s of H. pylori infection is not fully understood, T-helper (TH) lympho cytes may be subdivided into TH1 and TH2 cells based on the distinct p atterns of cytokine production, TH1 reaction is associated with immuni ty or resistance to infection, while TH2 reaction is associated with t he progression or persistence of infection, The production of interfer on-gamma (INF-gamma) and interleukin 2 (IL-2), which are type 1 cytoki nes, is decreased in H. pylori infection, Enhanced production of type 2 cytokines (IL-4) and IL-6) is observed in individuals with H. pylori infection, Suppressed proliferative responses of peripheral blood and gastric lymphocytes have also been demonstrated in patients with H. p ylori colonisation, suggesting that specific T-cell responses may be d own-regulated by an enhanced TH2 reaction, Suppressed TH1 and enhanced TH2 responses in H. pylori infection may be involved in the immunopat hogenesis of chronic H. pylori infection.