Over the last decade low power laser irradiation has been used to repa
ir nerves by photothermal welding. Nineteen animal and clinical experi
mental studies of laser tissue welding of nerves are reviewed. Possibl
e mechanisms of tissue welding are presented, together with the benefi
ts, limitations, and possible future implications of several technique
s used in laser nerve repair. The consensus of these studies is that n
erve welding has some advantages over standard suture repair. These ad
vantages include less neuroma- und scar formation and shorter repair t
ime. The major disadvantage of laser nerve repair is the initial infer
ior tensile strength. In the future, use of dyes or proteins could enh
ance the welding process by reinforcing the union strength, thus may i
mprove the results of this promising technique.