DEVELOPMENT AND EXPERIMENTAL APPLICATION OF RECEPTOR-SPECIFIC MR CONTRAST-MEDIA

The authors describe the feasibility of developing receptor-specific M R contrast agents for the improved detection of pathology and assessme nt of organ function. Receptor specificity of MR contrast agents can b e achieved by binding of receptor-specific carriers to ligands. This c oncept leads towards a decrease in dose and thus in toxicity. Specific attachment to parenchymal cells improves tumor-organ contrast and the refore tumor detection. Specific uptake mechanisms also enable the ass essment of organ function. Future design concepts of novel MR contrast agents may consider the desired uptake in specific cells or organs (o varies, adrenal glands, lymph nodes etc.) with subsequent synthesis of appropriate carriers.