SEMIQUANTITATIVE EVALUATION OF PAIN AND H EAT SENSATIONS DURING PERIPHERAL ANGIOGRAPHY - DOUBLE-BLIND INTRAINDIVIDUAL STUDY WITH IOMEPROL-350 AND IOPENTOL-350
K. Mathias et al., SEMIQUANTITATIVE EVALUATION OF PAIN AND H EAT SENSATIONS DURING PERIPHERAL ANGIOGRAPHY - DOUBLE-BLIND INTRAINDIVIDUAL STUDY WITH IOMEPROL-350 AND IOPENTOL-350, Radiologe, 36(2), 1996, pp. 164-168
The effect on pain and heat sensation of monomere non-ionic contrast m
edia with different osmolality was assessed in a randomized double-bli
nd study. Peripheral angiography was performed in 29 patients who suff
ered from chronic occlusive vessel disease, The two non-ionic contrast
media iomeprol and iopentol were applied intraindividually. The contr
ast media with an iodine concentration of 350 mg/ml had an osmolality
of 618 or 810 mosm/kg, A contrast medium volume of 80 or 90 ml was inj
ected in the abdominal aorta, The mean flow was 13.9 ml/s, The two con
trast medium injections were separated by an interval of 10 min, No an
algesic premedication was given, The pain and heat intensity was semiq
uantatively measured using a visual analogue scale ranging from 0 (no
heat/pain) to 100 (intractable heat/pain). The median after the first
injection was calculated as 40 for iomeprol and 70 for iopentol. The c
omparison of heat and pain sensations after the second injection showe
d a less distinct difference with a scale rating of 60 for iomeprol an
d of 65 for iopentol. The statistical variance was highly significant
(p < 0.01) in favor of iomeprol.