4 DUALLY RESISTANT HUMAN CYTOMEGALOVIRUS STRAINS FROM AIDS PATIENTS -SINGLE MUTATIONS IN UL97 AND UL54 OPEN READING FRAMES ARE RESPONSIBLEFOR GANCICLOVIR-SPECIFIC AND FOSCARNET-SPECIFIC RESISTANCE, RESPECTIVELY

Authors
BALDANTI F SARASINI A SILINI E BARBI M LAZZARIN A BIRON KK GERNA G
Citation
F. Baldanti et al., 4 DUALLY RESISTANT HUMAN CYTOMEGALOVIRUS STRAINS FROM AIDS PATIENTS -SINGLE MUTATIONS IN UL97 AND UL54 OPEN READING FRAMES ARE RESPONSIBLEFOR GANCICLOVIR-SPECIFIC AND FOSCARNET-SPECIFIC RESISTANCE, RESPECTIVELY, Scandinavian journal of infectious diseases, 1995, pp. 103-104
Citations number
10
Categorie Soggetti
Infectious Diseases
Journal title
Scandinavian journal of infectious diseases → ACNP
ISSN journal
00365548
Year of publication
1995
Supplement
99
Pages
103 - 104
Database
ISI
SICI code
0036-5548(1995):<103:4DRHCS>2.0.ZU;2-X
Abstract
Four human cytomegalovirus strains with double resistance to both ganc iclovir and foscarnet were recovered from acquired immunodeficiency sy ndrome (AIDS) patients, The four isolates were genetically unrelated a nd each of them consisted of a single viral population. In addition, f or each isolate, UL97 and UL54 open reading frames sequencing showed a single aminoacid change in a conserved domain of each of the two gene s.