We investigated the incidence and significance of proteinuria in recip
ients of liver transplants. The overall incidence of proteinuria was 5
9.72%. The peak incidence of proteinuria was at 3 months and at the en
d of 1 yr posttransplant. Proteinuria was higher in those patients who
developed posttransplant diabetes mellitus, and those who developed b
oth posttransplant diabetes and posttransplant hyperlipidemia. Patient
s who received higher total dosage of steroids and CsA had significant
ly greater proteinuria. Patients who had a Cr Cl greater than 50 ml/mi
n had greater proteinuria posttransplant for the first 6 months, but t
he trend was reversed later. We did not find any association of protei
nuria with age, weight, rejection episodes, or with the etiology of li
ver failure. Hypertension was a common occurrence in our patients, and
therefore its significance in the causation of proteinuria could not
be defined.