EPIDEMIOLOGY OF NOSOCOMIAL INFECTIONS DUE TO CLOSTRIDIUM-DIFFICILE

Clostridium difficile accounts for 15-25% of cases of antibiotic-assoc iated diarrhea (AAD) and for virtually all cases of antibiotic-associa ted pseudo-membranous colitis (PMC), This anaerobic bacterium is also carried in the gastro-intestinal tract of less than 3% of the normal a dult population and can be isolated from the feces of 50-70% asymptoma tic neonates, Since recent years, C. difficile has been identified as the leading cause of nosocomial diarrhea in adults, Pathogenesis relie s on a disruption of the normal bacteria flora of the colon, a coloniz ation with C. difficile and the release of toxins that cause mucosal d amage and inflammation. Incidence of C. difficile intestinal disorders varies between 1 to 30 per thousand patient admissions, Risk factors for C. difficile-associated diarrhea include antimicrobial therapy, ol der age (>65 years), intensive care, nasogastric tube, anti-acid use, and length of hospital stay, Nosocomial transmission of C. difficile v ia orofecal route occurs in 3-30% of total patient admissions but it o ften remains asymptomatic, Environmental contamination and carriage of the organism on the hands of hospital staff are common, Measures that are recommended to reduce cross-infection rely on an accurate and rap id diagnosis, implementation of enteric isolation, use of disposable g loves, hand washing with a suitable disinfectant (e.g. chlorhexidine) and daily environmental disinfection, C. difficile is a common cause o f infectious diarrhea and should be therefore systematically investiga ted in patients with nosocomial diarrhea.