CORRECTION OF SEVERE THROMBOCYTOPENIA WITH CHLOROQUINE IN THE PRIMARYANTIPHOSPHOLIPID SYNDROME

We describe a patient with Primary Antiphospholipid Syndrome (PAPS) an d severe thrombocytopenia with bleeding, in whom treatment with high d ose steroids failed to maintain a sustained level of platelets followi ng an initial short lived response. After several unsuccessful attempt s with Danazol and aspirin combined with low dose steroids, the platel ets count rose following the administration of chloroquine and low dos e steroids and remained in the normal range even when steroids were ta pered.