PHENOTYPIC-PROPERTIES AND FUNCTIONAL-PROPERTIES OF MURINE GAMMA-DELTA-T-CELL CLONES DERIVED FROM MALARIA IMMUNIZED, ALPHA-BETA-T-CELL-DEFICIENT MICE

Six murine T cell clones expressing gamma delta TCR were generated fro m malaria immunized, alpha beta T cell-deficient mice, Phenotypic char acterization of these clones has revealed that, in contrast to convent ional alpha beta T cells, there is a considerable degree of heterogene ity among these gamma delta clones with regard to their surface marker s and their lymphokine profile, One clone was found to display signifi cant anti-parasite activity in vivo upon adoptive transfer, We attempt ed to determine whether the protective clone differs in one or more ke y characteristics from the non-protective clones, Although no obvious pattern peculiar to the protective gamma delta clone was observed, it appears that more than one parameter may, in combination, define a dis tinct protective phenotype, and thus explain the functional difference between the protective and non-protective gamma delta clones.