MEMORY MODULATION BY POST-TRAINING GLUCOSE OR INSULIN REMAINS EVIDENTAT LONG RETENTION INTERVALS

Immediate posttraining intraperitoneal injection of alpha-D[+3]-glucos e (30 mg/kg) facilitated, whereas a nonconvulsive dose of insulin (8 I U/kg) impaired, 24-h retention, in male Swiss mice, of a one-trial ste p-through inhibitory avoidance task. When mice were trained and receiv ed immediate post-training glucose or insulin injections and were test ed for retention either 1 week or 1 month later, at each retention int erval performance was comparable to that found with a 24-h retention i nterval. Thus, memory modulation by post-training administration of ei ther glucose or insulin remain evident at long retention intervals. (C ) 1996 Academic Press, Inc.