A COMPARATIVE-STUDY OF THE EFFECTS OF TIMOLOL AND LATANOPROST ON BLOOD-FLOW VELOCITY OF THE RETROBULBAR VESSELS

PURPOSE: To examine the effects of topical timolol and latanoprost on retrobulbar vessel blood velocity in patients with glaucoma or ocular hypertension. METHODS: Nine patients with primary open-angle glaucoma and six patients with ocular hypertension were enrolled for this study . All patients were treated topically with 0.5% timolol or 0.005% lata noprost, using a double-masked crossover design with a 3-week washout before administration of each drug. Each patient had a baseline color Doppler imaging ultrasound of the central retinal artery, short poster ior ciliary arteries, and ophthalmic artery and two other ultrasound e xaminations during the 1-week treatment with each drug, performed 12 h ours after the first dose of the drug and 12 hours after the last dose , 7 days later. RESULTS: Both topical timolol and topical latanoprost significantly reduced the intraocular pressure. The only significant c hange observed in the retrobulbar blood velocity with timolol was a re duction of end diastolic velocity in the ophthalmic artery 12 hours af ter the first dose, accompanied by a trend toward a decrease in the pe ak systolic velocity and an increase in the resistance index in the sa me vessel. No change in blood velocity was observed with latanoprost. CONCLUSION: Topical timolol and latanoprost significantly reduced the intraocular pressure in ocular hypertensive and glaucoma patients with out creating substantial hemodynamic changes in the retrobulbar vessel s.