R. Gasser et al., CASES OF LYME BORRELIOSIS RESISTANT TO CONVENTIONAL TREATMENT - IMPROVED SYMPTOMS WITH CEPHALOSPORIN PLUS SPECIFIC BETA-LACTAMASE INHIBITION, Microbial drug resistance, 1(4), 1995, pp. 341-344
We present four cases of verified late Lyme borreliosis with persisten
t symptoms and positive serology despite repeated courses of high-dose
intravenous penicillin G and/or cephalosporins (including cefoperazon
e). The patients were now treated with cefoperazone 2 g plus sulbactam
1 g bid iv for 14 days. At the end of treatment, patients were sympto
m free and have remained so for the following 12 months, By then, IgG
against Borrelia burgdorferi had decreased. It is concluded that the a
ddition of beta-lactamase inhibitors to intravenous treatment could be
beneficial in Lyme disease refractory to conventional treatment.