B. Brembillaperrot et al., SIGNIFICANCE AND PREVALENCE OF INDUCIBLE ATRIAL TACHYARRHYTHMIAS IN PATIENTS UNDERGOING ELECTROPHYSIOLOGIC STUDY FOR PRESYNCOPE OR SYNCOPE, International journal of cardiology, 53(1), 1996, pp. 61-69
The purpose of the study was to report the prevalence of inducible sup
raventricular tachyarrhythmias (SVTA) in 827 consecutive patients aged
17 to 90 years who did not have spontaneous documented SVTA and who h
ad unexplained presyncope and/or syncope. The electrophysiologic study
(EPS) included programmed atrial and ventricular stimulation up to tw
o extrastimuli at three cycle lengths, and the study of sino-atrial an
d AV conduction. The results were as follows. EPS was normal in 386 pa
tients. Inducible junctional tachycardia or atrial flutter and fibrill
ation was the only finding in 187 patients (23%). In the remaining pat
ients we found ventricular tachycardia in 103 (12%), heart block in 67
(8%), sick sinus syndrome in 56 (7%) and increased vagal tone in 28 (
3%). The presence of an underlying heart disease (47%) and salves of a
trial premature beats on Holter monitoring (39%) were significantly co
rrelated with the induction of SVTA. However, the comparison with simi
lar groups without syncope indicates that only the induction of SVTA i
n patients with hypertrophic cardiomyopathy and mitral valve prolapse
was significantly correlated with the history of syncope. In patients
without heart disease or with prior myocardial infarction or decreased
left ventricular function, the induction of SVTA, which is not associ
ated with hypotension in the supine position, could require an inducti
on after head-up tilting, because of the lack of specificity of progra
mmed stimulation in these patients. Programmed atrial stimulation shou
ld be systematically performed in patients with unexplained syncope, i
n particular in those with hypertrophic cardiomyopathy and mitral valv
e prolapse, who require a specific treatment, if a SVTA is induced. In
other patients the results of programmed atrial stimulation should be
interpreted cautiously.