KINETICS OF GLUCOSE, INSULIN AND C-PEPTID E DURING TOCOLYSIS BY ORAL FENOTEROL

Objective: The effect of oral fenoterol therapy (40 mg/day) on the kin etics of glucose, insulin and C-peptide during an oral glucose toleran ce test (oGTT; 100 g glucose) was investigated in the third trimester. Methods: 54 patients without tocolytic therapy (25 with a pathologic oGTT) were compared with 36 patients who received tocolytic therapy (1 8 patients with a pathologic oGTT). Results: The patients with a norma l or pathologic oGTT and with or without tocolytic therapy showed no s ignificant differences in respect of the concentrations of glucose, in sulin and C-peptide. During tocolytic therapy, an early increase in in sulin was observed as well as slightly elevated C-peptide concentratio ns and a decreased C-peptide/insulin quotient.