RESTORATIVE EFFECT OF CORIOLUS-VERSICOLOR POLYSACCHARIDES AGAINST GAMMA-IRRADIATION-INDUCED SPLEEN INJURY IN MICE

Aim: To study the restorative effect of Coriolus versicolor polysaccha rides (CVP) on spleen injury induced by gamma-ray irradiation in mice. METHODS: ICR male mice, 6 - 8 wk old, were divided at random into 3 g roups: A) normal control; B) irradiated with 1 Gy; and C) after 1 Gy i rradiation, given CVP 60 mg . g(-1)(ig) daily for 10 d continuously. B ody weight (BW), spleen weight (SW), relative SW (RSW), DNA synthesis of splenocytes (DNA-SS), and relative DNA-SS were measured on d 5, 12, 19, 26, and 33 after irradiation. RESULTS: SW, RSW, DNA-SS, and relat ive DNA-SS decreased after irradiation. CVP enhanced the recovery of S W, RSW, DNA-SS, and relative DNA-SS inhibited by irradiation. CONCLUSI ON: CVP has the restorative effect against spleen injury induced by ga mma-ray irradiation in mice.