VOGT-KOYANAGI-HARADA DISEASE AND HLA TYPE IN ITALIAN PATIENTS

PURPOSE: To study the frequencies of human leukocyte antigen (HLA) spe cificities in Italian patients with Vogt-Koyanagi-Harada disease and t o correlate the presence of each specificity to the clinical features. METHODS: Human leukocyte antigen specificities were determined by sta ndard microlymphocyto-toxicity assay in 16 patients with Vogt-Koyanagi -Harada disease and compared with HLA specificities of 116 healthy con trols, RESULTS: HLA-DR4 was statistically related to Vogt-Koyanagi-Har ada disease (P = .0063), whereas only a trend toward a significant ass ociation between the disease and HLA-B41 was found (P = .06). HLA-DQ1 was detected in a disproportionate number of controls (68.9%) compared with patients (31.5%). CONCLUSIONS: HLA-DR4 was significantly related to Vogt-Koyanagi-Harada disease in Caucasian European patients, speci fically in Italian patients, as it was described in other racial group s. No clear relation was found between the ophthalmologic and systemic manifestations of Vogt-Koyanagi-Harada disease and the presence of HL A specificities.