Alkaline encrusted cystitis is a rare inflammatory condition of the bl
adder which has been reported sporadically over the past 80 years. It
is caused by infection with urea splitting organisms leading to the de
position of inorganic salts on to the surface of the bladder, We prese
nt three cases of alkaline encrusted cystitis, In two cases the encrus
ted area was associated with foci of malakoplakia. The third case occu
rred in a patient who had received chemotherapy for acute lymphoblasti
c leukaemia. To our knowledge, these are the first cases of malakoplak
ia associated with alkaline encrusted cystitis. These two conditions h
ave a number of clinical and aetiological similarities, and may have m
ore in common than has been previously thought.