N. Kameoka et al., POSTPRANDIAL RESPONSES OF LIVER BLOOD-FLOW PRIOR TO AND FOLLOWING HEPATECTOMY IN CONSCIOUS DOGS, The Journal of surgical research, 61(2), 1996, pp. 437-443
The responses of the portal and hepatic arterial blood flows to variou
s diets and nutrients were measured simultaneously in conscious dogs p
rior to and following hepatic resection, Prior to hepatectomy, the inc
rease in the portal blood flow was significantly larger in response to
an elemental diet, fats, or amino acids than to glucose or water. The
peak increase was 60.2 +/- 14.4 mi for water, 144.7 +/- 22.1 mi for a
150-cal elemental diet, 168.5 +/- 16.1 mi for a 300-cal elemental die
t, 86.7 +/- 14.0 mi for a glucose solution, 159.3 +/- 16.7 mi for an a
mino acid meal, and 188.5 +/- 25.3 mi for a fat meal, Following partia
l hepatectomy, fats and amino acids induced an increase in the portal
blood flow similar to that prior to hepatectomy, Glucose and the eleme
ntal diet, on the other hand, induced a significantly larger increase
in portal blood flow following the surgery although water did not, The
peak increase was 144.4 +/- 27.8 mi for glucose (166% of the peak inc
rease prior to hepatectomy) and 221.8 +/- 32.5 mi for the 300-cal elem
ental diet (132%), The postprandial response of the hepatic artery to
every diet was quite different among the dogs and there were no signif
icant changes both prior to and following surgery. The different respo
nse of the portal flow to intraluminal glucose following partial hepat
ectomy may be due to alterations in glucose metabolism following hepat
ectomy. We have shown that the postprandial response of the portal blo
od flow varies with the type of nutrient, and it can be altered by hep
atectomy. (C) 1996 Academic Press, Inc.