RELATIONAL DATABASE MODEL FOR DNA MUTATIONS AND A SOFTWARE PROGRAM FOR IMPLEMENTATION OF THE MODEL

A relational database model for describing DNA mutations is presented. The model was developed in conjunction with the human hprt database a nd was successful in representing over 1800 hprt mutations, Mutants sh owing aberrant mRNA splicing can be adequately described using the mod el, as well as mutants showing more than one mutation. The basic aspec ts of the relational model should be applicable to mutations in a vari ety of genes, A data entry program developed using Microsoft Access 2. 0 is also described that implements the relational model. The data ent ry program ensures that relational integrity is maintained between the tables and automatically generates key fields as needed, The pro,sram also has the ability to convert between the various numbering schemes that are used to describe base pair location in the hprt gene, The pr ogram and source code are placed in the public domain so that other ex perimenters can adapt the program for use with other genes.