Alternative drugs to chloroquine are required to prevent the deleterio
us effects of malaria in pregnancy. Fear of potential toxicity has lim
ited antimalarial drug use in pregnancy. Animal toxicity studies have
documented teratogenicity when antimalarials are administered at high
dosages. Excepting the tetracyclines, there is no evidence to suggest
that, at standard dosages, any of the antimalarial drugs are teratogen
ic. Primaquine is not recommended because of the potential risk of hae
molytic effects in the fetus, Rates of spontaneous abortion and birth
defects were comparable in pregnant women taking mefloquine, compared
with chloroquine-proguanil, or pyrimethamine-sulfadoxine prophylaxis,
in the first trimester of pregnancy, Standard doses of quinine do not
increase the risk of abortion or preterm delivery, Therapeutic mefloqu
ine does not provoke hypoglycaemia. There is no evidence in the litera
ture to support the hypothetical risk of kernicterus in the newborn, f
ollowing exposure to antimalarial drugs containing sulphonamides or su
lphones prior to delivery, Documentation of the safety of doxycycline,
halofantrine, and the artemisinin derivatives in the treatment of mal
aria in pregnant women is currently limited.