TRIMETHOPRIM AND SULFONAMIDE-ASSOCIATED MENINGOENCEPHALITIS WITH MRI CORRELATES

Early recognition of trimethoprim and sulfonamide-induced aseptic meni ngitis is important because drug cessation leads to rapid clinical imp rovement. We present clinical and laboratory findings in two typical c ases. In both cases, MRI revealed previously undescribed diffuse white matter abnormalities that resolved within a few months. These MRI fin dings are important because they may aid in early diagnosis of this co ndition in the appropriate clinical setting. In addition, the white ma tter abnormalities suggest an encephalitic component in addition to th e meningitis.