THE SEQUENCE OF A DROSOPHILA CYP4E2 CYTOCHROME P450-ENCODING CDNA

Authors
PITTENDRIGH BR MOCELIN G ANDREEV O FFRENCHCONSTANT RH
Citation
Br. Pittendrigh et al., THE SEQUENCE OF A DROSOPHILA CYP4E2 CYTOCHROME P450-ENCODING CDNA, Gene, 179(2), 1996, pp. 295-296
Citations number
6
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
179
Issue
2
Year of publication
1996
Pages
295 - 296
Database
ISI
SICI code
0378-1119(1996)179:2<295:TSOADC>2.0.ZU;2-8
Abstract
A composite 1458-bp cDNA that encodes cytochrome P450 (P450) Cyp4e2 ha s been constructed from clones isolated from two Drosophila embryonic cDNA libraries. The Drosophila cDNA open reading frame encodes a prote in of 486 amino acids that is 40% identical and 61% similar to Cyp4d1 from Drosophila. The predicted protein is unusual in that it appears t o lack the hydrophobic N-terminus typical of microsomal P450s and also contains a small insertion at its C-terminus.