COMPARISON OF THE 5'-UPSTREAM REGION OF THE EVOLUTIONARILY EQUIVALENTPOLYUBIQUITIN GENE OF HUMANS AND CHINESE-HAMSTERS

The 5' upstream region of the Chinese hamster polyubiquitin gene CHUB2 was determined, and compared to that of the evolutionarily equivalent polyubiquitin gene UbC of humans. The 5' upstream region of the CHUB2 gene is distinct from that of the UbC gene in containing fewer recogn ition sequences for binding of transcription factors, which are quite sparsely distributed in this region. It seemed probable that the absen ce of AP-1 sites in the promoter of the CHUB2 gene was likely to be re sponsible for the very dissimilar regulation of the two genes by UV li ght and TPA, despite the fact that these genes are evolutionarily equi valent.