RELATIONSHIP OF HAPTOGLOBIN-RELATED PROTEIN (OA-519) TO NEWER PROGNOSTIC MARKERS IN BREAST-CANCER - AN IMMUNOHISTOCHEMICAL STUDY ON ROUTINEPARAFFIN SECTIONS

The primary objective of this study was to compare the prognostic perf ormance of the haptoglobin related protein OA-519 with both estrogen a nd progesterone receptors, as well as with a cohort of 6 non-tradition al prognostic markers: pS2, proliferating cell nuclear antigen, epider mal growth factor receptor, c-erbB-2, p53 and DF3. We examined 99 case s of invasive breast cancer using immunohistochemical methods on routi ne paraffin sections, 68 of which had sufficient demographic data for multivariate analyses. The statistical results indicate that only 1 fa ctor, stage, had significant predictable power for patient survivabili ty (stage 3-hazard ratio = 6.039: p-value = <0.0005; stage 4-hazard ra tio = 7.599, p-value = <0.0005). These findings indicate that OA-519 i s not any more informative a prognostic marker than the other markers used in this study.