ADRENAL-TUMOR PRODUCING 11-DEOXYCORTICOSTERONE, 18-HYDROXY-11-DEOXYCORTICOSTERONE AND ALDOSTERONE

A case of adrenal tumor producing 11-deoxycorticosterone, 18-hydroxy-1 1-deoxycorticosterone and aldosterone is reported, A 55-year-old woman had hypertension, hypokalemia, low plasma renin activity and an adren al tumor, The plasma level of aldosterone was normal, and the levels o f 11-deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone were ex tremely high, After the tumor removal, the plasma level of aldosterone decreased and plasma levels of 11-deoxycorticosterone and 18-hydroxy- 11-deoxycorticosterone were normalized, The tumor was benign adenoma a nd the production of steroid hormones was under control of adrenocorti cotropic hormone, The enzyme activity of 21-hydroxylation in the tumor was elevated and that of 11 beta-hydroxylation was decreased compared with the adjacent tissue.