HEREDITARY MULTIPLE EXOSTOSES - CONFIRMATION OF LINKAGE TO CHROMOSOME-8 AND CHROMOSOME-11

Hereditary multiple exostoses (EXT) is an autosomal dominant disorder characterized by the formation of cartilage capped prominences that de velop from the epiphyses of the long bones, EXT is heterogeneous with three different locations currently identified on chromosomes 8, 11, a nd 19, Recently, we identified and studied 12 large multigenerational EXT families, Linkage analyses demonstrates that 6 of these families m ap to 8q24 and 6 to 11p, None of the families map to the chromosome 19 locus, The results suggest that there are two major loci, on chromoso mes 8 and 11, involved in the cause of EXT, The locus on chromosome 19 remains to be confirmed. (C) 1996 Wiley-Liss, Inc.