EFFECTS OF SELENIUM AND VITAMIN-E ON THE IMMUNE-RESPONSES OF DOMESTIC-ANIMALS

The gross effects of selenium and vitamin E deficiency on animal produ ction and the potential benefits of supplementation are recognised, an d the influence of these micronutrients on the resistance of animals t o a variety of infections has also been reported. As a result, deficie ncies could compromise the immune system and result in a decline in pr oduction and performance before gross effects become apparent. Data ob tained by laboratories studying different animal species indicate that the responses of domestic animals, particularly ruminants, differ fro m those of human beings and laboratory animals as well as differing am ong themselves. This paper provides a comprehensive review of the effe cts of selenium and vitamin E on the immune responses of domestic anim als and discusses their effects with respect to the differences in the basal nutritional status of the animals concerned, the type of supple ments used, the route and timing of their administration and the diffe rent agents which have been used to stimulate an immune response.