NEW GERMAHETEROCYCLES, GERMADITHIOACETALS AND A GERMYLATED OXIDE AND SULFIDE DERIVED FROM CYSTEAMINE, METHYLCYSTEAMINE AND N-SUBSTITUTED CYSTEAMINE - SYNTHESIS AND RADIOPROTECTIVE ACTIVITY

Further to our work concerning organometallic compounds active in chem ical radioprotection, we report the synthesis and pharmacological stud y (radioprotective activity, toxicity) of new germathiazolidines and g ermadithioacetals derived from cysteamine, methylcysteamine and N-subs tituted cysteamine. A germylated oxide and sulfide with methylcysteami ne hydrochloride as ligand were also investigated. A notable decrease in the toxicity and a fairly large increase in the radioprotective act ivity of these new organogermylated compounds were observed compared w ith cysteamine, methylcysteamine and N-substituted cysteamine.