ANDROGENIC REGULATION OF PROTEIN-KINASE CK1 IN THE PROSTATIC CELL

We examined the androgenic regulation of protein kinase CK1 in rat ven tral prostate cytosolic and chromatin fractions. On androgen deprivati on, CK1 in both the nuclear and cytoplasmic compartments decreases slo wly at a similar rate. Stimulation of regrowth in the prostate does no t evoke an early differential modulation in the CK1 because it increas es in both the cytosol and chromatin only by 24 h after androgenic sti mulus. These changes in CK1 relate to its proposed role in cell regula tion at mitosis and differ from those in protein kinase CK2 that demon strates rapid modulations in the nuclear compartment under similar con ditions.