Mohs micrographic surgery is a technique by which skin cancers are exc
ised with complete, three-dimensional microscopic control of all surgi
cal margins, allowing the detection and excision of all subclinical tu
mor extensions. Successive layers of tissue are removed, and the entir
e undersurface and peripheral epidermal edge are examined histological
ly, typically with frozen sections.(1-3)This approach is ideally appli
ed to skin cancer excision, because most lesions grow in a contiguous
fashion. Consequently, microscopic extensions, which often extend well
beyond the clinically apparent margins,(4) can be detected and traced
out after microscopic examination of the entire surgical margin. The
precise nature of the technique also allows the preservation of uninvo
lved tissues and obviates removal of predetermined margins of clinical
ly normal skin.