SYNTHESIS AND PHYSIOLOGICAL-ACTIVITY OF NEW ORGANOPHOSPHORUS PESTICIDES OF 1,3,2-OXAZAPHOSPHORINANE SERIES

Methods for the synthesis of 2-aryloxy(arylthio)- and y(alkylthio)-2-t hio(oxo)-1,3,2-oxazaphosphorinanes and their N-substituted derivatives based on the reactions of the corresponding dichlorophosphates, dichl orothio-, and dithiophosphates with 3-aminopropan-1-ol or its substitu ted derivatives in the presence of Et(3)N or aqueous alkali under phas e transfer catalysis conditions, as well as by the reaction of the tet ramethylammonium salt of 2-hydroxy-2-thio-1,3,2-oxazaphosphorinane wit h alkyl- and acyl halides, by that of 2-chloro-2-thio-1,3,2-oxazaphosp horinane with sodium thiolates. and by other methods, were developed. The compounds obtained exhibit high nematocide activity but low toxici ty for mammals. Some active synergists for permethrine were found amon g these compounds.