THE SYNTHESIS OF NOVEL ANALOGS OF THE MANUMYCIN FAMILY OF ANTIBIOTICSAND THE ANTITUMOR ANTIBIOTIC LL-C10037-ALPHA

Authors
KAPFER I LEWIS NJ MACDONALD G TAYLOR RJK
Citation
I. Kapfer et al., THE SYNTHESIS OF NOVEL ANALOGS OF THE MANUMYCIN FAMILY OF ANTIBIOTICSAND THE ANTITUMOR ANTIBIOTIC LL-C10037-ALPHA, Tetrahedron letters, 37(12), 1996, pp. 2101-2104
Citations number
38
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
12
Year of publication
1996
Pages
2101 - 2104
Database
ISI
SICI code
0040-4039(1996)37:12<2101:TSONAO>2.0.ZU;2-P
Abstract
Efficient approaches to the central amino-epoxycyclohexenone core of t he manumycin family of antibiotics are described, The use of this meth odology to prepare the antitumour antibiotic LL-C10037 alpha and its e pimer, both in racemic form, and a number of analogues of manumycin, a lisamycin and asukamycin, lacking the C-4 substituent, ate then outlin ed.