SELECTIVE FORMATION OF HYDROXY-3,3-BIS(HYDROXYMETHYL)-GAMMA-BUTYROLACTONE FROM FORMALDEHYDE ON HYDROTALCITE-TYPE CATALYSTS

Authors
MIZUTANI T MIKI Y NAKASHIMA R FUJITA H OGOSHI H
Citation
T. Mizutani et al., SELECTIVE FORMATION OF HYDROXY-3,3-BIS(HYDROXYMETHYL)-GAMMA-BUTYROLACTONE FROM FORMALDEHYDE ON HYDROTALCITE-TYPE CATALYSTS, Bulletin of the Chemical Society of Japan, 69(2), 1996, pp. 425-429
Citations number
28
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Chemical Society of Japan → ACNP
ISSN journal
00092673
Volume
69
Issue
2
Year of publication
1996
Pages
425 - 429
Database
ISI
SICI code
0009-2673(1996)69:2<425:SFOH>2.0.ZU;2-E
Abstract
As a model for prebiotic sugar formation under neutral to acidic condi tions, reactions of formaldehyde over hydrotalcite-type catalysts were investigated. Heating an aqueous solution of formaldehyde at 140-200 degrees C for 12 h over Ni-Fe hydrotalcite-type catalyst afforded hydr oxy-3,3-bis(hydroxymethyl)-gamma-butyrolactone selectively, a 5.8% yie ld based on gas-liquid chromatographic analysis. The structure was ide ntified by H-1 and (13)CNMR and H-1-C-13 HSQC, HMBC and C-13-C-13 2D I NADEQUATE NMR experiments.