PREPARATIONS OF N-ALPHA-FMOC-O-[(BENZYLOXY)HYDROXYPHOSPHINYL] BETA-HYDROXY-ALPHA-AMINO ACID-DERIVATIVES

Authors
WAKAMIYA T NISHIDA T TOGASHI R SARUTA K YASUOKA J KUSUMOTO S
Citation
T. Wakamiya et al., PREPARATIONS OF N-ALPHA-FMOC-O-[(BENZYLOXY)HYDROXYPHOSPHINYL] BETA-HYDROXY-ALPHA-AMINO ACID-DERIVATIVES, Bulletin of the Chemical Society of Japan, 69(2), 1996, pp. 465-468
Citations number
19
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Chemical Society of Japan → ACNP
ISSN journal
00092673
Volume
69
Issue
2
Year of publication
1996
Pages
465 - 468
Database
ISI
SICI code
0009-2673(1996)69:2<465:PONB>2.0.ZU;2-Y
Abstract
N-alpha-Fmoc-O-[(benzyloxy)hydroxyphosphinyl] serine and N-alpha-Fmoc- O-[(benzyloxy)hydroxyphosphinyl] threonine were prepared in order to b e utilized for the synthesis of phosphoserine- or phosphothreonine-con taining peptides based on the Fmoc-mode pre-phosphorylation strategy. These derivatives were obtained as crystalline compounds, which are fa vorable for use as building blocks for an automated peptide synthesis by a solid-phase method.