SYNTHESIS OF ANTITUMOR LYCORINES BY INTRAMOLECULAR DIELS-ALDER REACTION

Authors
PEREZ D BURES G GUITIAN E CASTEDO L
Citation
D. Perez et al., SYNTHESIS OF ANTITUMOR LYCORINES BY INTRAMOLECULAR DIELS-ALDER REACTION, Journal of organic chemistry, 61(5), 1996, pp. 1650-1654
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
61
Issue
5
Year of publication
1996
Pages
1650 - 1654
Database
ISI
SICI code
0022-3263(1996)61:5<1650:SOALBI>2.0.ZU;2-X
Abstract
Pharmacologically interesting lycorines were obtained by a short, effi cient method based on an intramolecular Diels-Alder reaction between a n alpha-pyrone and an alkyne, followed by loss of CO2 in a retro Diels -Alder reaction. The cyclization precursors (pyrones 9) were obtained in good yields in two or three steps from the corresponding homophthal ic acid or anhydride.