SYNTHESIS AND ANTITUMOR-ACTIVITY OF NEW TRANS-1R,2R-DIAMINOCYCLOHEXANEPLATINUM(II) COMPLEXES CONTAINING DISUBSTITUTED SULFIDE GROUPS

Authors
SHAMSUDDIN S ALBAKER S SIDDIK ZH KHOKHAR AR
Citation
S. Shamsuddin et al., SYNTHESIS AND ANTITUMOR-ACTIVITY OF NEW TRANS-1R,2R-DIAMINOCYCLOHEXANEPLATINUM(II) COMPLEXES CONTAINING DISUBSTITUTED SULFIDE GROUPS, Inorganica Chimica Acta, 241(2), 1996, pp. 101-104
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Inorganica Chimica Acta → ACNP
ISSN journal
00201693
Volume
241
Issue
2
Year of publication
1996
Pages
101 - 104
Database
ISI
SICI code
0020-1693(1996)241:2<101:SAAONT>2.0.ZU;2-6
Abstract
A series of cationic platinum(II) complexes of the form [Pt(DACH)(R'R' 'S)Cl]NO3, (where DACH = trans-1R,2R-diaminocyclohexane, and R'R''S = dimethylsulfide, diethylsulfide, dipropylsulfide, diisopropylsulfide, diphenylsulfide, dibenzylsulfide, thioanisole and methyl-p-tolylsulfid e) have been synthesized and characterized by elemental analysis, IR, H-1 and Pt-195 NMR spectroscopic techniques. Some of these analogs wer e as active as cisplatin in the in vivo leukemia L1210/0 tumor model.