METHOTREXATE-INDUCED LEUKOENCEPHALOPATHY - A CASE-REPORT

A six-year-old girl with non-Hodgkin's lymphoma who was treated with b oth intravenous (IV) and intrathecal (IT) methotrexate and developed b rain damage secondary to the cytostatic drug is described. This patien t displayed hypertension, hypothermia/hyperthermia, lethargy, deterior ation and coma as clinical findings, and bilateral, focal white matter hyperintensities in the occipital lobes were seen in her magnetic res onance imaging (MRI). Treatment-related leukoencephalopathy is one suc h adverse effect of IT methotrexate administration on the central nerv ous system and usually appears in a generalized form.