SECONDARY ACUTE MYELOBLASTIC-LEUKEMIA IN A CHILD WITH ACUTE LYMPHOBLASTIC-LEUKEMIA TREATED WITH EPIPODOPHYLLOTOXINS

Authors
OZBEK N CETIN M TUNCER AM YETGIN S
Citation
N. Ozbek et al., SECONDARY ACUTE MYELOBLASTIC-LEUKEMIA IN A CHILD WITH ACUTE LYMPHOBLASTIC-LEUKEMIA TREATED WITH EPIPODOPHYLLOTOXINS, Turkish Journal of Pediatrics, 37(3), 1995, pp. 279-282
Citations number
8
Categorie Soggetti
Pediatrics
Journal title
Turkish Journal of Pediatrics → ACNP
ISSN journal
00414301
Volume
37
Issue
3
Year of publication
1995
Pages
279 - 282
Database
ISI
SICI code
0041-4301(1995)37:3<279:SAMIAC>2.0.ZU;2-I
Abstract
Etoposide is a semi-synthetic, topoisomerase active podophyllotoxin de rivative which frequently causes deletions end rearrangements on chrom osomes 11q23 and 11q22. It can cause therapy-related, acute myeloblast ic leukemia in patients receiving the drug in a schedule-dependent man ner. Here we present a case with acute lymphoblastic leukemia who deve loped secondary acute myeloblastic leukemia 28 months after the beginn ing of therapy which contained etoposide on an every-other-week schedu le.