The occurrence of immune thrombocytopenic purpura (ITP) in Hodgkin's d
isease is uncommon. This report describes a patient who developed ITP
twice before splenectomy, and for the third time several years later,
preceding an abdominal relapse of the disease. We suggest that patient
s with a history of Hodgkin's disease undergo diligent searches for ac
tive disease when ITP is diagnosed. ITP may be the only manifestation
of active disease and may preceed histologic documentation of Hodgkin'
s disease by months or years.