Rw. Flint et Dc. Riccio, GLUCOSE-ADMINISTRATION ATTENUATES HYPOTHERMIA-INDUCED RETROGRADE-AMNESIA IN RATS IN A TIME-DEPENDENT AND DOSE-DEPENDENT MANNER, Psychobiology, 24(1), 1996, pp. 62-66
It is well established that posttraining administrations of glucose en
hance memory in a time- and dose-dependent manner. More recently, gluc
ose has also been found to attenuate scopolamine-induced anterograde a
mnesia, displaying the same time- and dose-response characteristics (S
tone et al., 1988). In the present study, the use of glucose as an age
nt for alleviation of hypothermia-induced retrograde amnesia was exami
ned. In each experiment, animals were given a single trial of passive
avoidance conditioning. Retrograde amnesia was induced through hypothe
rmia immediately following training. All injections were given immedia
tely following hypothermia treatment, and tests for fear retention wer
e administered 24 h following training. In Experiment 1, the dose-resp
onse effects of glucose (10, 100, or 400 mg/kg) were examined;in Exper
iment 2, the time-dependent effect of 100 mg/kg of glucose administere
d immediately, 1, or 2 h after hypothermia was examined. The results s
how that glucose injections attenuate retrograde amnesia in both a dos
e- and time-dependent manner. These results coincide with the growing
body of evidence supporting the memory-modulating effects of glucose.