The Holliday junction is a well-known intermediate of homologous recom
bination. Recently, the proteins involved in the correct processing of
the Holliday structure into mature recombinant molecules, namely RuvA
, RuvB, RuvC and RecG have been isolated and characterized. This has c
ulminated in a model for their synergistic mechanism of action and the
solving of the RuvC crystal structure.