EXPERIENCE WITH POORLY MYELOSUPPRESSIVE CHEMOTHERAPY SCHEDULES FOR ADVANCED MYELOMA

Authors
BRUGNATELLI S RICCARDI A UCCI G MORA O BARBARANO L PIVA N PICCININI L BERGONZI C DEPAOLI A DISTASI M RINALDI E TROTTI G PETRINI M ASCARI E
Citation
S. Brugnatelli et al., EXPERIENCE WITH POORLY MYELOSUPPRESSIVE CHEMOTHERAPY SCHEDULES FOR ADVANCED MYELOMA, British Journal of Cancer, 73(6), 1996, pp. 794-797
Citations number
22
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
73
Issue
6
Year of publication
1996
Pages
794 - 797
Database
ISI
SICI code
0007-0920(1996)73:6<794:EWPMCS>2.0.ZU;2-G
Abstract
In a multicentre study, 83 patients with advanced and previously unifo rmly treated multiple myeloma (MM) were randomised between cyclophosph amide (600 mg m(-2)) and epirubicin (70 mg m(-2)), administered every 3 weeks for three courses and both associated with prednisone and inte rferon-alpha 2b. Both regimens were administered on an outpatient basi s and had low haematological toxicity. Clinical results were similar. Overall response rate (43%) and median response and survival (5.9 and 14.1 months respectively) compare well with those obtained with more a ggressive chemotherapy schedules.