ETOPOSIDE IN LANGERHANS CELL HISTIOCYTOSIS IN CHILDREN - A PRELIMINARY EXPERIENCE

Treatment of langerhans cell histiocytosis (LCH) is yet to be establis hed. We treated seven patients with etoposide alone at a dose of 100 m g/m(2)/day for 3 days given every 3 to 4 weeks for sir cycles. Three p atients had received prior chemotherapy, two patients were less than 2 years of age, and two had liver dysfunction. A positive response to t herapy was seen in five patients. There was no major toxicity. Etoposi de therapy is safe and effective in the treatment of LCH.