HIV-infected patients with persistent fever can be encouraged to use a
spirin or acetaminophen if the source of the fever has been establishe
d. The initial observation that acetaminophen enhances the potential o
f zidovudine (Retrovir) to cause neutropenia has not been subsequently
confirmed. Comparable to the diagnostic approach to persistent fever
in other patients, evaluation of fever in HIV-infected patients requir
es an empathic physician who provides a comprehensive, systematic asse
ssment consistent with sound medical knowledge as well as an understan
ding of the importance of preserving the patient's quality of life. Pe
rhaps in no other area of clinical medicine is the need for a valid pa
rtnership and a trusting relationship between patient and physician mo
re essential than in the care of HIV-infected patients.