When they were discovered by Acher and co-workers, neurophysins were t
hought to act as carriers for the active nonapeptides vasopressin (AVP
) and oxytocin (OT) and were then recognized as the inactive fragment
of a precursor with a higher molecular weight (propressophysin). The r
ole of neurophysins in the hypothalamo-neurohypophyseal system is now
being reconsidered in the light of crystallographic and molecular biol
ogy research and the recent definition of the different deletions or s
ubstitutions that cause central diabetes insipidus in rats (Brattlebor
o) or human beings. Apparently, any disruption of the strucuture and/o
r conformation of neurophysins (by genic substitution or deletion) may
cause a decline in the binding and the activity of the endopeptidase
responsible for the cleavage of the AVP. The disruption may also produ
ce a change in the polymerization of neurophysins and salt bridges rel
ating this to the neuropeptides, with the result that there is an acce
lerated aspecific enzymatic degradation of the hormone revealing clini
cal symptomatology. So, rather than being a mere inactive part of the
precursor, neurophysins are now equally regarded as a system for carry
ing and protecting nonapeptides.