CHRONIC RECURRENT MULTILOCAL OSTEOMYELITIS (CRMO)

Pathogenesis of CRMO still remains unknown. Characteristic, but not pa thognomonic for this syndrome are clinical course (age, sex, chronic r ecurrent, intermittent course), radiological findings (metaphyseal les ions), histology (chronic osteomyelitis without colliquation) and micr obiological results (lack of pathogen, infectious agents). Favorable, self-limited long-term prognosis of CRMO has been assumed. Antibiotics provide no improvement. Course, severity and recurrency can be influe nced positively by antiphlogistic substances, although this has not ye t been proved. Whether surgical intervention beyond biopsies might cau se improvement on the follow-up is unknown. Our experience (4 cases), and the literature demonstrate great clinical importance that unusual types of osteomyelitis (OM) can be within the differential diagnosis o f multifocal osteolytic changes.