TRANSPORT OF THE ANTIBACTERIAL AGENT (6S)-6-FLUOROSHIKIMATE AND OTHERSHIKIMATE ANALOGS BY THE SHIKIMATE TRANSPORT-SYSTEM OF ESCHERICHIA-COLI

Authors
JUDE DA EWART CDC THAIN JL DAVIES GM NICHOLS WW
Citation
Da. Jude et al., TRANSPORT OF THE ANTIBACTERIAL AGENT (6S)-6-FLUOROSHIKIMATE AND OTHERSHIKIMATE ANALOGS BY THE SHIKIMATE TRANSPORT-SYSTEM OF ESCHERICHIA-COLI, Biochimica et biophysica acta. Biomembranes, 1279(2), 1996, pp. 125-129
Citations number
12
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1279
Issue
2
Year of publication
1996
Pages
125 - 129
Database
ISI
SICI code
0005-2736(1996)1279:2<125:TOTAA(>2.0.ZU;2-A
Abstract
We show that the antibacterial agent, (6S)-6-fluoroshikimate, is a sub strate for the shikimate transport system of Escherichia coli because in exchange-diffusion experiments it displaced intracellular [C-14]shi kimate with the same kinetics as did unlabelled shikimate. Other shiki mate analogues were also substrate: as judged by similar experiments o r, in the case of (6R)-6-fluoroshikimate, by inference.