Ek. Chapnick et al., COMPARATIVE KILLING KINETICS OF METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS BY BACITRACIN OR MUPIROCIN, Infection control and hospital epidemiology, 17(3), 1996, pp. 178-180
The in vitro activities of bacitracin and mupirocin were compared for
seven different strains of methicillin-resistant Staphylococcus aureus
. Six of seven strains showed bacitracin minimum inhibitory concentrat
ions (MICs) of 0.5 to 1.0 units/mL, and all seven had mupirocin MICs o
f 0.5 to 2 mu g/mL. Time-kill studies revealed 2.6- to 4.5-log reducti
on in 24 hours with strains susceptible to bacitracin (4 units/mL) and
0 to 2.2 reduction with mupirocin (16 mu g/mL). Bacitracin should be
considered further for in vivo studies because of enhanced bacteriocid
al effect and lower cost.