ORGAN-TRANSPLANTATION AFTER ONCOLOGIC THE RAPY IN CHILDHOOD

The improved results of cancer therapy justify a careful and critical analysis of delayed adverse sequelae. Chemotherapy, radiotherapy and s urgery can variably damage different tissues and organs. In case of ir reversible organ failure organ transplantation might be an option for some long-term survivors. We report on three patients, who received or gan transplants following haemato-oncologic therapy. The first patient developed anthracycline-induced cardiomyopathy refractory to medical management 10 years after chemotherapy for B cell lymphoma and was tre ated successfully by heart transplantation. The second patient with Wi lms tumor and Denys-Drash syndrome developed end - stage renal failure 10 months after discontinuation of therapy, which was treated by neph rectomy, hemodialysis and renal transplantation. The third patient und erwent successful allogeneic bone marrow transplantation for congenita l sideroblastic anemia but later developed chronic graft versus host d isease of the liver inducing biliary cirrhosis. Five years after BMT a successful liver transplantation was performed.