PURPOSE AND METHODS: Two hundred fifty-eight consecutive nonsedated co
lonoscopies were prospectively evaluated over an 18-month period. The
cecum was intubated in 250 cases (97 percent). Polypectomies or biopsi
es were performed in 77 cases (31 percent). Indications for colonoscop
y included history of polyps (32 percent), hematochezia (28 percent),
family history of colon cancer (16 percent), prior history of colon ca
ncer (9 percent), change in bowel habits (12 percent), abnormal flexib
le sigmoidoscopy (6 percent), and inflammatory bowel disease (3 percen
t). RESULTS. Sedation was withheld for the following reasons: patient
preference (57 percent), medical problems (2 per cent), prior resectio
n (16 percent), surgeon preference (6.5 percent), lack of intravenous
access (3 percent), and age (1 percent). Three patients (1.5 percent)
required sedation to complete the procedure. Procedure-related pain wa
s based on a scale from zero to three. One hundred thirty-nine patient
s (61 percent) rated their pain as either zero (no pain) or one (mild
pain), and 217 percent (8 percent) indicated that they would prefer th
eir next colonoscopy to be performed without sedation. One hundred twe
lve patients had previously undergone sedated colonoscopy. Ninety-two
(92 percent) preferred nonsedated to sedated procedures. Average proce
dure time was 13.7 (range, 0.5 to 85) minutes. CONCLUSIONS: Several se
ries have studied nonsedated endoscopic upper and lower gastrointestin
al evaluations. None, however, have evaluated patient comfort and sati
sfaction. In our prospective series of 258 consecutive nonsedated colo
noscopies, we found the procedure to be safe, effective, and well acce
pted.